Vincristine toxicity unrelated to dose.

The protective effects of saffron stigma alcoholic extract against vincristine sulfate drug-induced renal toxicity in rat

Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tissue. This study aimed to evaluate the protective effect of alcoholic extract of saffron stigma against vincristine renal toxicity in male rats. Methods: A total number of 50 rats were randomly divided into 10 groups. Different doses of VCR (0.25, 0.5 and 0.75mg/kg) and saffron (0.5 and ...

Prolonged Vincristine Toxicity Induced by Concurrent Posaconazole in a Child with T-cell Acute Lymphoblastic Leukemia

Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats

Background: Hepatoprotective effects of Fumaria parviflora have been approved in pharmaceutical and chemical toxicity models. Given the importance of the vincristine- induced hepatotoxicity during chemotherapy, the aim of this study was to investigate the potential hepatoprotective effects of F. parviflora extract on vincristine induced toxicity in adult male rats. Materials and methods: In thi...

Drug Toxicity and Increased Activity against Murine L1210 and Liposomal Vincristine Preparations Which Exhibit Decreased

The toxicity and antitumor activity of liposomal vincristine prepara tions have been examined. Vincristine was encapsulated inside egg phosphatidylcholine (EPC)/cholesterol (55/45, mol/mol) and distearoylphosphatidylcholine (DSPC)/cholesterol (55/45, mol/mol) vesicles utilizing transmembrane pH gradient (inside acidic) drug uptake processes. Trap ping efficiencies approaching 100% were achieved...

Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukemia.

10049 Background: Vincristine is one of the corner stitches in the treatment of children with acute lymphoblastic leukemia (ALL). Constipation and other peripheral and central neurotoxicities are the most common side effects. Drugs interfering with the metabolism of vincristine might potentiate these side effects. A group of drugs that interact with the metabolism of vincristine are azoles. Sev...